1.Chen PY, Wang CY, Tsao EC, Chen YT, Wu MJ, Ho CT, Yen JH (2022) 5-Demethylnobiletin Inhibits Cell Proliferation, Downregulates ID1 Expression, Modulates the NF-κB/TNF-α Pathway and Exerts Antileukemic Effects in AML Cells. Int J Mol Sci. 23, 7392.
https://doi.org/10.3390/ijms23137392 (7/2022) (IF=6.208, 69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
2.Wu PS, Wang CY, Chen PS, Hung JH, Yen JH, Wu MJ* (2021) 8-Hydroxydaidzein Downregulates JAK/STAT, MMP, Oxidative Phosphorylation, and PI3K/AKT Pathways in K562 Cells. Biomedicines. 9, 1907.
https://doi.org/10.3390/biomedicines9121907. (12/2021) (IF= 4.757, 86/279 in PHARMACOLOGY & PHARMACY)
3.Chen PY, Gao WY, Liou JW, Lin CY, Wu MJ, Yen JH. (2021) Angiopoietin-Like Protein 3 (ANGPTL3) Modulates Lipoprotein Metabolism and Dyslipidemia. Int J Mol Sci. 22, 7310. (7/2021) (IF=6.208, 69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
4.Gao WY, Chen PY, Hsu HJ, Lin CY, Wu MJ, Yen JH. (2021) Tanshinone IIA Downregulates
Lipogenic Gene Expression and Attenuates Lipid Accumulation through the Modulation of LXRα/SREBP1 Pathway in HepG2 Cells. Biomedicines. 9: 326 (3/2021) (IF= 4.757, 86/279 in PHARMACOLOGY & PHARMACY)
5.Wu PS, Yen JH, Wang, CY, Chen PY, Hung JH, Wu MJ* (2020) 8-Hydroxydaidzein, an Isoflavone from Fermented Soybean, Induces Autophagy, Apoptosis, Differentiation, and Degradation of Oncoprotein BCR-ABL in K562 Cells. Biomedicines. 8(11): 506 (11/2020) (IF= 4.757, 86/279 in PHARMACOLOGY & PHARMACY)
6.Wu PS, Jeng J, Yang JJ, Kao V, Yen JH, Wu MJ* (2020) Vernonia patula (Dryand.) Merr. and Leucas chinensis (Retz.) R. Brown exert anti-inflammatory activities and relieve oxidative stress via Nrf2 activation. J Ethnopharmacol. 262:113155 (7/2020) (IF= 5.195, 4/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)
7.Yen JH, Lin CY, Chuang CH, Chin HK, Wu MJ, Chen PY (2020) Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells. Cells. 2020, 9(4):877; doi:10.3390/cells9040877 (4/2020) (IF= 7.666, 51/194 in Cell biology)
8.Shen KH, Hung JH, Liao YC, Tsai ST, Wu MJ, Chen PS (2020) Sinomenine Inhibits Migration and Invasion of Human Lung Cancer Cell through Downregulating Expression of miR-21 and MMPs. Int J Mol Sci. 21(9):3080 (1/2020)
9.Thang SK, Chen PY, Gao WY, Wu MJ, Pan MH, Yen JH. (2019) Xanthohumol Suppresses NPC1L1 Gene Expression through Downregulation of HNF-4α and Inhibits Cholesterol Uptake in Caco-2 Cells. J Agric Food Chem. 67(40):11119-11128 (10/2019) (IF= 5.895, 6/59 in AGRICULTURE, MULTIDISCIPLINARY)
10.Chang HY, Wu JR, Gao WY, Lin HR, Chen PY, Chen CI, Wu MJ, Yen JH. (2019) The Cholesterol-Modulating Effect of Methanol Extract of Pigeon Pea (Cajanus cajan (L.) Millsp.) Leaves on Regulating LDLR and PCSK9 Expression in HepG2 Cells. Molecules. 24(3): 493. doi: 10.3390/molecules24030493 (01/2019)(IF= 4.927, 82/224 in Chemistry, MULTIDISCIPLINARY)
11.Chen PY, Chen YT, Gao WY, Wu MJ, Yen JH. (2018) Nobiletin Down-Regulates c-KIT Gene Expression and Exerts Antileukemic Effects on Human Acute Myeloid Leukemia Cells. J Agric Food Chem. 66(51):13423-13434. (12/2018) (IF= 5.895, 6/59 in AGRICULTURE, MULTIDISCIPLINARY)
12.Gao WY, Chen PY, Chen SF, Wu MJ, Chang HY, Yen JH.(2018) Pinostrobin inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) gene expression through the modulation of FoxO3a protein in HepG2 cells. J Agric Food Chem. 66(24):6083-6093. (06/2018) (IF= 5.279, 4/75 in CHEMISTRY, APPLIED)
13.Wu PS, Ding HY, Yen JH, Chen SF, Lee KH, Wu MJ*. (2018) Anti-inflammatory activity of 8-hydroxydaidzein in LPS-stimulated BV2 microglial cells via activation of Nrf2-antioxidant and attenuation of Akt/NF-kappaB-inflammatory signaling pathways, as well as inhibition of COX-2 activity. J Agric Food Chem. 66(23):5790-5801. (06/2018) (IF= 5.279, 4/75 in CHEMISTRY, APPLIED)
14.Chen PY, Tien HJ, Chen SF, Tang HL, Jung HL, Wu MJ, Yen JH. (2018) Response of Myeloid Leukemia Cells to Luteolin is Modulated by Differentially Expressed Pituitary Tumor-Transforming Gene 1 (PTTG1) Oncoprotein. Int J Mol Sci. 2018; 19(4):1173 (04/2018)
15.Chen SF, Chen PY, Hsu HJ, Wu MJ, Yen JH. (2017) Xanthohumol Suppresses Mylip/Idol Gene Expression and Modulates LDLR Abundance and Activity in HepG2 Cells. J Agric Food Chem. 65(36):7908-7918. doi: 10.1021/acs.jafc.7b02282. (09/2017)
16.Yen J-H, Wu P-S, Chen S-F, Wu M-J*. (2017) Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells. Int J Mol Sci. 18(4): 852. doi:10.3390/ ijms18040852 NSC 102-2320-B-041-003-MY3 (04/2017)
17.Shen KH, Hung JH, Chang CW, Weng YT, Wu MJ, Chen PS*. (2017) Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression. Chem Biol Interact. 268:129-135. (IF= 5.168; 18/94 in Toxicology) (03/2017)
18.Chen HC, Chen PY, Wu MJ, Tai MH, Yen JH* (2016) Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells. PLoS One. 11(9):e0162414 (IF= 3.240, 29/126 in MULTIDISCIPLINARY SCIENCES, NSC 102-2320-B-041-003-MY3) (09/2016)
19.Ding HY, Wu PS, Wu MJ* (2016) Cleome rutidosperma and Euphorbia thymifolia Suppress Inflammatory Response via Upregulation of Phase II Enzymes and Modulation of NF-B and JNK Activation in LPS-Stimulated BV2 Microglia. Int J Mol Sci. 17(9). pii: E1420. NSC 102-2320-B-041-003-MY3 (08/2016)
20.Chiou SY, Ha CL, Wu PS, Yeh CL, Su YS, Li MP, Wu MJ* (2015) Antioxidant, Anti-Tyrosinase and Anti-Inflammatory Activities of Oil Production Residues from Camellia tenuifloria. Int J Mol Sci. 16(12): 29522-29541. doi:10.3390/ijms161226184. NSC 102-2320-B-041-003-MY3 (12/2015)
21.Huang SL, Chen PY, Wu MJ, Tai MH, Ho CT, Yen JH* (2015) Curcuminoids Modulate the PKCδ/NADPH oxidase/ROS Signaling Pathway and Suppress Matrix Invasion during Monocytes-Macrophages Differentiation. J Agric Food Chem. 63(40):8838-48. (10/2015)
22.Wu PS, Yen JH, Kou MC, Wu MJ*. (2015) Luteolin and apigenin attenuate 4-hydroxy-2-nonenal-mediated cell death through modulation of UPR, Nrf2-ARE and MAPK pathways in PC12 cells. PLoS One 10(6):e0130599. NSC 102-2320-B-041-003-MY3) (06/2015)
23.Chen PY, Wu MJ, Chang HY, Tai MH, Ho CT, Yen JH. (2015) Up-regulation of miR-34a expression in response to the luteolin-induced neurite outgrowth of PC12 cells. J Agric Food Chem. 63(16):4148-4159. (04/2015)
24.Chen PY, Ho YR, Wu MJ, Huang SP, Chen PK, Tai MH, Ho CT, Yen JH (2015) Cytoprotective effects of fisetin against hypoxia-induced cell death in PC12 cells. Food Funct. 6(1):287-96. (IF= 6.317, 24/143 in FOOD SCIENCE & TECHNOLOGY, 01/2015)
25.Tai MH, Chen PK, Chen PY, Wu MJ, Ho CT, Yen JH (2014) Curcumin enhances cell-surface LDLR level and promotes LDL uptake through down-regulation of PCSK9 gene expression in HepG2 cells. Mol Nutr Food Res. 58(11):2133-45. (IF= 6.575, 29/164 in FOOD SCIENCE & TECHNOLOGY, 11/2014)
26.Wang L, Chiou S.-Y., Shen Y.-T., Yen, F.-T., Ding H.-Y., Wu M.-J.*(2014) Anti-Inflammatory Effect and Mechanism of the Green Fruit Extract of Solanum integrifolium Poir. Biomed Res Int. 2014: 953873. (IF= 3.246, 90/158 in BIOTECHNOLOGY & APPLIED MICROBIOLOGY, NSC102-2320-B-041-003-MY3) (08/2014)
27.Hu LW, Yen JH, Shen YT, Wu KY, Wu MJ* (2014) Luteolin modulates 6-hydroxydopamine-induced transcriptional changes of stress response pathways in PC12 cells. PLoS One 9(5):e97880. (NSC-99-2320-B-041-005-MY3 and NSC 102-2320-B-041-003-MY3) (05/2014)
28.Lin MH, Yen JH, Weng CY, Wang L, Ha CL, Wu MJ* (2014) Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: roles of ROS and MAPK pathways. Toxicology 315:24-37 DOI:10.1016/j.tox.2013.11.007. (SCI, IF= 4.571, 22/94 in TOXICOLOGY, NSC-99-2320-B-041-005-MY3 and NSC 102-2320-B-041-003-MY3)(01/2014)
29.Weng CY, Chiou SY, Wang L, Kou MC, Wang YJ*, Wu MJ* (2014) Arsenic trioxide induces unfolded protein response in vascular endothelial cells. Arch Toxicol. 88(2):213-26. DOI 10.1007/s00204-013-1101-x NSC-99-2320-B-041-005-MY3 (SCI, IF= 6.168, 12/94 in Toxicology) (02/2014)
30.Chiu SP, Wu MJ, Chen PY, Ho YR, Tai MH, Ho CT, Yen JH (2013) Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 61:9453-63. DOI: 10.1021/jf4024678. (10/2013)
31.Chiu HW, Chen MH, Fang WH, Hung CM, Chen YL, Wu MD, Yuan GF, Wu MJ*, Wang YJ. (2013) Preventive effects of monascus on androgen-related diseases: androgenetic alopecia, benign prostatic hyperplasia, and prostate cancer. J Agric Food Chem. 61(18):4379-86. 05/2013)
32.Kou MC, Fu SH, Yen JH, Weng CY, Li S, Ho CT and Wu MJ*. (2013) Effects of citrus flavonoids, 5-hydroxy-3,6,7,8,3’,4’-hexamethoxyflavone and 3,5,6,7,8,3’,4’-heptamethoxyflavone, on the activities of macrophage scavenger receptors and the hepatic LDL receptor. Food Funct. 2013, 4 (4), 602 - 609 (SCI) NSC-96-2320-B-041-006-MY3 (04/2013)
33.Kou MC, Chiou SY, Weng CY, Wang L, Ho CT, Wu MJ*. (2013) Curcuminoids distinctly exhibit antioxidant activities and regulate expression of scavenger receptors and heme oxygenase-1. Mol Nutr Food Res. 57(9)1598-1610. NSC-96-2320-B-041-006-MY3 (09/2013)
34.Lin LF, Chiu SP, Wu MJ, Chen PY, Yen JH*. (2012) Luteolin induces microRNA-132 expression and modulates neurite outgrowth in PC12 Cells. PLoS One 7(8): e43304. (08/2012)
35.Wang L, Kou MC, Weng CY, Hu LW, Wang YJ*, Wu MJ*. (2012) Arsenic modulates heme oxgenase-1, interleukine-6 and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB and MAPK pathways. Arch Toxicol. 86(6): 879-896 (04/2012)
36.Liao KK, Wu MJ, Chen PY, Huang SW, Chiu SJ, Ho CT, Yen JH*. (2012) Curcuminoids Promote Neurite Outgrowth in PC12 Cells through MAPK/ERK- and PKC-Dependent Pathways. J Agric Food Chem. 60: 433−443 (01/2012) NSC-99-2320-B-041-005-MY3
37.Su JD, Yen JH, Li S, Weng CY, Lin MH, Ho CT, Wu MJ* (2012) 3',4'-didemethylnobiletin induces Phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells. Free Radic Biol Med. 52(1):126-141. (SCI, IF= 8.101, 22/146 in ENDOCRINOLOGY & METABOLISM) (01/2012) NSC-99-2320-B-041-005 –MY
38.Lai HC, Wu MJ, Chen PY, Sheu TT, Chiu SP, Lin MH, Ho CT, Yen JH* (2011). Neurotrophic Effect of Citrus 5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: Promotion of Neurite Outgrowth via cAMP/PKA/CREB Pathway in PC12 Cells. PLoS One 6(11):e28280 (11/2011) NSC-99-2320-B-041-005-MY3 (2011,11)
39.Foo NP, Lin SH, Lee YH, Ho YS, Wu MJ*, Wang YJ* (2011) -Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β. Toxicology. 282(1-2):39-46 (03/2011)
40.Wang L, Weng CY, Wang Y-J* and Wu MJ* (2011) Lipoic acid ameliorates arsenic trioxide-induced HO-1 expression and oxidative stress in THP-1 monocytes and macrophages. Chem Biol Interact. 190(2-3):129-38. (04/2011) (NSC-96-2320-B-041-006-MY3)
41.Yen JH, Weng CY, Li S, Lo YH, Pan MH, Fu SH, Ho CT, Wu MJ* (2011) Citrus flavonoid, 5-demethylnobiletin, suppresses scavenger receptor expression in THP-1 cells and alters lipid homeostasis in HepG2 liver cells. Mol Nutr Food Res. 55(5):733-48. (05/2011) NSC-96-2320-B-041-006-MY3